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COVID19: Delaying second dose of vaccine increases risk of new resistant strain, Sage papers reveal

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Warning over ‘realistic possibility’ of resistant strains of the virus emerging

London, Jan 23: Delaying doses of coronavirus inoculations will increase the chances of a vaccine-resistant strain of Covid-19 emerging, scientists have warned.

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In new reports, released by the Scientific Advisory Group for Emergencies (Sage), experts also warned that resistant new variants were a “realistic possibility” driven by the virus reacting to increasing levels of natural immunity among the population.

In papers released on Friday, Sage scientists said there was an “increased risk of virus replication under partial immunity after one dose than after two doses, so in the short term, delaying the second dose would be expected to somewhat increase the probability of emergence of vaccine resistance – but probably from a low base.

“Is such an increase material?

It is not currently possible to quantify the probability of emergence of vaccine resistance as a result of the delayed second dose, but it is likely to be small.

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“In the current circumstances the unquantifiable but likely small probability of the delayed second dose generating a vaccine escape mutant must be weighed against the measurable benefits of doubling the speed with which the most vulnerable can be given vaccine-induced protection.”

But the paper added: “Given what we have observed recently with the variants B.1.1.7 and B1.351, it is a realistic possibility that over time immune escape variants will emerge, most likely driven by increasing population immunity following natural infection.”It warned: “Vaccine efficacy after one dose should be carefully monitored to inform future vaccine policy.”

Sir Patrick Vallance, the chief scientific adviser, told a Downing Street press conference on Friday that the virus was likely to be around “forever”, adding:

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The most risky thing in terms of new mutation is to have very high prevalence. The more the virus is transmitting and replicating between people the more likely it will get a mutation, and that is what is happening around the world”.

That’s the biggest risk.

There is always some risk if you start to have partial immunity, but there is also a benefit which is partial immunity can actually stop the infection quicker.”

Chris Whitty, the U.K government’s chief medical adviser, said:

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“All of medicine is about balance of risk. Our overall view was that the balance of risk was firmly in favour at this stage of the epidemic in the UK of having many more people vaccinated but that does mean a delay. That particular risk was a much smaller risk of not having people vaccinated which was the alternative.”

All viruses mutate and natural variations in the Sars-CoV-2 virus have been identified across the globe and the Sage paper said this was likely to happen at a “faster rate” as greater numbers of people become immune after infection.

It added: “Most mutations will be inconsequential, but a few may, by chance, confer a functional advantage over others and, through natural selection may become dominant laboratory-generated variants.”

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It said there was “theoretical and experimental data supporting the possibility” that the virus could generate new variants which would “evade” antibody therapies, convalescent plasma, and vaccines as well as natural immunity.

The paper said vaccinated people who went on to develop Covid-19 need to have their virus genetically sequenced “as quickly as possible to understand whether viral variation may explain the breakthrough”.

Increased sequencing of tests would help identify new clusters and spot changes as they emerge after the vaccine rollout.

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J&K grapples with doubling of Heart attacks in past 5 years

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Heart attacks and strokes in Jammu & Kashmir have been rising, much like the rest of the world, and experts have identified pollution, insufficient exercise, and excessive consumption of fast foods as the primary factors contributing to this trend.

Also Read: 28 police officers from J&K inducted in IPS

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Cardiologists at several tertiary healthcare facilities in the Union Territory, revealed that the number of heart attacks in Jammu & Kashmir has nearly doubled over the past five years. They said the hospitals here have witnessed an almost twofold increase in the number of stent procedures performed in the last two years alone.

Dr A G Ahanger, a renowned Cardiologist, informed KNO that heart disease is responsible for approximately 27-31% of all deaths worldwide. However, about 85% of these deaths can be preventable if treated promptly, he said.

The doctor emphasised that any symptoms associated with heart disease should not be disregarded, and a proper investigation should be done to diagnose and treat the condition and save lives.

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He suggested that people must adopt the 5S policy to minimize the risk of heart disease, which includes reducing SALT and SUGAR intake, avoiding SEDENTARY lifestyle, managing STRESS, and quitting SMOKING. Following these guidelines could help save lives and promote a healthy heart, he said.

Dr. Irfan, a cardiologist at GMC Srinagar, told KNO that the rate of heart attacks at SKIMS or SMHS has doubled over the last five years. “There has been a change in the pattern of heart attacks. In the past, there would be 70% fewer cases in the summers than in the winters. However, this is not the case anymore. We are now admitting more young patients with heart-related issues, and performing stent procedures and pacemaker implantations frequently,” he said.

According to Dr Irfan, air pollution, rapid urbanisation, drug abuse, sedentary lifestyle, physical inactivity, fast food intake, stress, and smoking are all reasons behind the increased prevalence of hypertension and diabetes, which in turn lead to heart attacks. He also noted that young patients with heart problems were rare some years ago, but now it has become a daily routine.

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Dr Irfan commented on the current situation in Kashmir, stating that many people have become reliant on others and are not taking responsibility for their own actions. He identified a trend towards seeking out only comfortable and easy work, which has been further enabled by the rise of online delivery systems and the work-from-home culture.

“Unfortunately, this sedentary lifestyle has contributed to a rise in drug abuse and associated health problems, including Endocarditis disease, which had previously been uncommon in the region. Even college-going females have been reported to be struggling with heart-related issues due to drug abuse,” he said.

The doctor lamented that while Kashmir has made strides in terms of technological advancements, the population’s overall health has suffered due to a lack of physical activity.

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He advised that managing conditions like high blood pressure, diabetes, and cholesterol, as well as avoiding a sedentary lifestyle, quitting smoking, reducing stress, eating a vegetable-rich diet, maintaining a healthy weight, and regularly exercising can significantly lower the risk of heart attacks.

According to cardiologists, common symptoms of a heart attack include chest pain that feels like pressure, tightness, squeezing, or aching. The pain or discomfort may also radiate to the shoulder, arm, back, neck, jaw, teeth, or upper belly. Other symptoms can include cold sweat, fatigue, heartburn or indigestion, lightheadedness or sudden dizziness, nausea, and shortness of breath. KNO

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Schools shut, curbs imposed after two die of Nipah virus in Kerela

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Some schools shut and curbs imposed on public gathering in Kerala after two people died of Nipah, a virus from bats or pigs that causes deadly fever.

Also Read: Youth killed another injured in Srinagar road accident

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The virus has no vaccine and a fatality rate ranging from 40 to 75 percent, according to the World Health Organization.

Symptoms include intense fever, vomiting and a respiratory infection, but severe cases can involve seizures and encephalitis, an inflammation of the brain, and result in a coma.

The Nipah virus strain seen in the state was the Bangladesh variant that spreads from human to human and has a high mortality rate, though it is less infectious, the government said. “People living in forest areas have to take the highest precautions,” George had said, adding that the latest case of the Nipah virus originated within five kilometres of a jungle area.

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In the wake of the rising Nipah virus cases, neighbouring Tamil Nadu state announced that travellers coming from Kerala would be subjected to medical tests and those with flu symptoms would be isolated.

700 people including 153 health workers who came in contact with those infected are under observation, health officials said.

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Doctors remove 13 hairpins, 5 safety pins, 5 razor blades from man’s stomach

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A group of talented medical professionals from a private hospital in Puducherry saved a 20-year-old man’s life by successfully removing 13 hairpins, 5 safety pins, and 5 razor blades from his stomach via an endoscopic technique.

The young man was hospitalised with disturbing symptoms, including intense abdominal pain, blood vomiting, and strange bowel motions, according to the experts at the Gastroenterology and Medical Centre (GEM) Hospital. After further inspection, it was discovered that he had 13 hairpins, 5 safety pins, and 5 razor blades in his stomach.

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“He has been dealing with psychiatric issues since childhood. Initially, he denied swallowing any foreign objects. However, during the endoscopic procedure, we discovered a hardened mass in his stomach. This collection of objects is referred to as a ‘foreign body bezoar,’ which could potentially lead to intestinal blockages and perforations,” explained Dr. K Sasikumar, a surgical gastroenterologist who led the medical team, as pee local media reports.

Facing this intricate situation, the team decided to opt for an endoscopic procedure instead of open surgery. Dr. K Sugumaran, another member of the team, stated, “The patient’s parents were also inclined towards avoiding open surgery. We proposed inserting a tube through the mouth to reach the stomach and safely remove these sharp objects. It was a challenging procedure given the nature of the objects.”

The patient was admitted to the hospital on August 7, and the procedure, lasting approximately two hours, took place on August 8. Fortunately, the patient responded positively to the treatment, and he was discharged the following day, on August 9. He even resumed a regular oral diet on the very same evening, as confirmed by Dr. K Sasikumar.

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The dedicated medical team responsible for this extraordinary accomplishment included medical gastroenterologist Dr. G Rajesh and anesthesiologist Dr. Ranjith. Dr. C Palanivelu, Chairman of GEM Hospitals, praised the team for their outstanding efforts in saving the young man’s life.

Doctors suspect that the patient consumed these sharp objects after mixing them with food. The condition of the patient is stable and he has been discharged from hospital.

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