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Pfizer-BioNTech likely to be effective against new mutant COVID-19 variant; Study

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Texas, Jan 08: Pfizer Inc and BioNTechs COVID-19 vaccine appeared to work against a key mutation in the highly transmissible new variants of the coronavirus discovered in Britain and South Africa, according to a laboratory study conducted by the U.S. drugmaker.


The study by Pfizer and scientists from the University of Texas Medical Branch, which has not yet been peer-reviewed, indicated the vaccine was effective in neutralizing virus with the so-called N501Y mutation of the spike protein.

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The mutation could be responsible for greater transmissibility and there had been concern it could also make the virus escape antibody neutralization elicited by the vaccine, said Phil Dormitzer, one of Pfizers top viral vaccine scientists.


The first results of tests on the variants offer a glimmer of hope while more studies are carried out as Britain and other countries try to tame the more infectious variants which authorities believe are driving a surge in infections that could overwhelm healthcare systems.


The Pfizer-BioNTech study was conducted on blood taken from people who had been given the vaccine. Its findings are limited because it does not look at the full set of mutations found in either of the new variants of the rapidly spreading virus.

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Dormitzer said it was encouraging that the vaccine appears effective against the mutation, as well as 15 other mutations the company has previously tested against.


“So weve now tested 16 different mutations, and none of them have really had any significant impact. Thats the good news,” he said. “That doesnt mean that the 17th wont.”


Dormitzer said another mutation found in the South African variant, called the E484K mutation, was also concerning. The researchers plan to run similar tests to establish whether the vaccine is effective against other mutations found in the British and South African variants and hope to have more data within weeks. The variants are said by scientists to be more transmissible than previously dominant ones, but they are not thought to cause more serious illness.

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Scientists said the results of the study would help calm concerns that people will not be protected by vaccines being given to millions of people around the world in the fight against the pandemic, which has killed more than 1.8 million people and roiled economies.


But they cautioned that more clinical tests and data are still needed to come to a definitive conclusion.


“This is good news, mainly because it is not bad news,” said Stephen Evans, professor of pharmacoepidemiology, London School of Hygiene & Tropical Medicine.

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“So, yes this is good news, but it does not yet give us total confidence that the Pfizer (or other) vaccines will definitely give protection.”


AstraZeneca, Moderna and CureVac are also testing whether their shots work against the fast-spreading variants. They have said they expect them to be effective, but the timing of those studies are not known. A senior British lawmaker expressed concerns in an interview on Friday that COVID-19 vaccines might not work properly against the South African variant. He was not responding to questions about Friday`s data.


The Pfizer/BioNTech vaccine and the one from Moderna Inc, which use synthetic messenger RNA technology, can be quickly tweaked to address new mutations of a virus if necessary. Scientists have suggested the changes could be made in as little as six weeks.

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The variant is not the first of the pandemic to emerge and Eleanor Riley, professor of immunology and infectious disease at the University of Edinburgh, said these types of study will be needed as they appear. “It may be necessary to tweak the vaccine over time,” she said.

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Schools shut, curbs imposed after two die of Nipah virus in Kerela

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Some schools shut and curbs imposed on public gathering in Kerala after two people died of Nipah, a virus from bats or pigs that causes deadly fever.

Also Read: Youth killed another injured in Srinagar road accident

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The virus has no vaccine and a fatality rate ranging from 40 to 75 percent, according to the World Health Organization.

Symptoms include intense fever, vomiting and a respiratory infection, but severe cases can involve seizures and encephalitis, an inflammation of the brain, and result in a coma.

The Nipah virus strain seen in the state was the Bangladesh variant that spreads from human to human and has a high mortality rate, though it is less infectious, the government said. “People living in forest areas have to take the highest precautions,” George had said, adding that the latest case of the Nipah virus originated within five kilometres of a jungle area.

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In the wake of the rising Nipah virus cases, neighbouring Tamil Nadu state announced that travellers coming from Kerala would be subjected to medical tests and those with flu symptoms would be isolated.

700 people including 153 health workers who came in contact with those infected are under observation, health officials said.

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Doctors remove 13 hairpins, 5 safety pins, 5 razor blades from man’s stomach

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A group of talented medical professionals from a private hospital in Puducherry saved a 20-year-old man’s life by successfully removing 13 hairpins, 5 safety pins, and 5 razor blades from his stomach via an endoscopic technique.

The young man was hospitalised with disturbing symptoms, including intense abdominal pain, blood vomiting, and strange bowel motions, according to the experts at the Gastroenterology and Medical Centre (GEM) Hospital. After further inspection, it was discovered that he had 13 hairpins, 5 safety pins, and 5 razor blades in his stomach.

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“He has been dealing with psychiatric issues since childhood. Initially, he denied swallowing any foreign objects. However, during the endoscopic procedure, we discovered a hardened mass in his stomach. This collection of objects is referred to as a ‘foreign body bezoar,’ which could potentially lead to intestinal blockages and perforations,” explained Dr. K Sasikumar, a surgical gastroenterologist who led the medical team, as pee local media reports.

Facing this intricate situation, the team decided to opt for an endoscopic procedure instead of open surgery. Dr. K Sugumaran, another member of the team, stated, “The patient’s parents were also inclined towards avoiding open surgery. We proposed inserting a tube through the mouth to reach the stomach and safely remove these sharp objects. It was a challenging procedure given the nature of the objects.”

The patient was admitted to the hospital on August 7, and the procedure, lasting approximately two hours, took place on August 8. Fortunately, the patient responded positively to the treatment, and he was discharged the following day, on August 9. He even resumed a regular oral diet on the very same evening, as confirmed by Dr. K Sasikumar.

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The dedicated medical team responsible for this extraordinary accomplishment included medical gastroenterologist Dr. G Rajesh and anesthesiologist Dr. Ranjith. Dr. C Palanivelu, Chairman of GEM Hospitals, praised the team for their outstanding efforts in saving the young man’s life.

Doctors suspect that the patient consumed these sharp objects after mixing them with food. The condition of the patient is stable and he has been discharged from hospital.

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Jaundice outbreak in Budgam’s Khansahib: Locals blame poor water quality as one dies, 38 test positive

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The locals have blamed poor water quality for the jaundice outbreak in the Riyar area of Khansahib block in central Kashmir’s Budgam district.

Also Read: Pizza date turns tragic as man falls to death from a terrace while hiding from GF’s father

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The locals told that the Jal Shakti Department has failed to provide safe drinking water in the village, which has led to the outbreak of jaundice and claimed the life of a minor.

“The water is polluted and infected as the water tank hasn’t been cleaned for decades,” they alleged.

The people have requested the authorities to take serious note of the “life-threatening” issue.

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A health official told that so far, 38 jaundice cases have been reported in the area and among them one person has died while the condition of others is stable.

He said that a 10-year-old boy identified as Abid, son of Abdul Salam from Riyar village of Khansahib, who was tested positive for jaundice following a jaundice outbreak, triggered by the supply of contaminated water.

Dr Mir Mushtaq, spokesperson of the Directorate of Health Services Kashmir (DHSK) told that “untiring” efforts are being made at Raiyar to curb jaundice through surveillance and rapid response teams of block Khansahib.

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Simultaneously, the paediatric patients have been seen by the Pediatrician at SDH, Khansahib and blood tests have been conducted for detecting the disease, he said, adding that the screening process is on and thousands of people have been screened so far in the area.

“The situation is under control,” the DHSK spokesperson said.

Already, around 2,000 people have been screened among which 38 have been reported positive, he said, adding that no positive case was reported in the last three days.

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“The ASHA workers of the concerned areas along with health workers have been distributing chlorine tablets and ORS packets among the inhabitants at door steps while field staff are continuously educating the people to take safe drinking water and also demonstrating the steps of hand washing to the people of this area,” Mushtaq said. KNO

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