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Depression, stress could moderate viability of COVID19 antibodies: Study

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With ANI inputs

New delhi, Jan 17: A study published in Perspectives on Psychological Science shows that downturn, stress, loneliness, and chronic weakness practices can debilitate the body’s immune system and lower the adequacy of specific antibodies.

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A study published in Perspectives on Psychological Science shows that downturn, stress, loneliness, and chronic weakness practices can debilitate the body’s immune system and lower the adequacy of specific antibodies.

The report proposes that the equivalent might be valid for the new COVID-19 immunizations that are being developed and the beginning phases of worldwide distribution.

Fortunately, it may be possible to reduce these negative effects with simple steps like exercise and sleep.Vaccines are among the safest and most effective advances in medical history, protecting society from a wide range of otherwise devastating diseases, including smallpox and polio. The key to their success, however, is ensuring that a critical percentage of the population is effectively vaccinated to achieve so-called herd immunity.

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Even though rigorous testing has shown that the COVID-19 vaccines approved for distribution in the United States are highly effective at producing a robust immune response, not everyone will immediately gain their full benefit. Environmental factors, as well as an individual’s genetics and physical and mental health, can weaken the body’s immune system, slowing the response to a vaccine.

This is particularly troubling as the novel coronavirus continues to rage across the world, trigging a concurrent mental health crisis as people deal with isolation, economic stressors, and uncertainty about the future. These challenges are the same factors that have been previously shown to weaken vaccine efficacy, particularly among the elderly.

“In addition to the physical toll of COVID-19, the pandemic has an equally troubling mental health component, causing anxiety and depression, among many other related problems.

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Emotional stressors like these can affect a person’s immune system, impairing their ability to ward off infections,” said Annelise Madison, a researcher at The Ohio State University and lead author on the paper.

“Our new study sheds light on vaccine efficacy and how health behaviors and emotional stressors can alter the body’s ability to develop an immune response. The trouble is that the pandemic in and of itself could be amplifying these risk factors.”

Vaccines work by challenging the immune system. Within hours of a vaccination, there is an innate, general immune response on the cellular level as the body begins to recognize a potential biological threat. This frontline response by the immune system is eventually aided by the production of antibodies, which target specific pathogens. It is the continued production of antibodies that helps to determine how effective a vaccine is at conferring long-term protection.

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“In our research, we focus most heavily on the antibody response, though it is just one facet of the adaptive immune system’s response,” said Jce Kiecolt-Glaser, director of the Institute for Behavioral Medicine Research at The Ohio State University and senior author on the paper.

The good news, according to the researchers, is that the COVID-19 vaccines already in circulation are approximately 95% effective. Even so, these psychological and behavioural factors can lengthen the amount of time it takes to develop immunity and can shorten the duration of immunity.

“The thing that excites me is that some of these factors are modifiable, it’s possible to do some simple things to maximize the vaccine’s initial effectiveness,” said Kiecolt-Glaser.

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Based on prior research, one strategy the researchers suggest is to engage in vigorous exercise and get a good night’s sleep in the 24 hours before vaccination so that your immune system is operating at peak performance. This may help ensure that the best and strongest immune response happens as quickly as possible.

“Prior research suggests that psychological and behavioural interventions can improve vaccine responsiveness. Even shorter-term interventions can be effective. Therefore, now is the time to identify those at risk for a poor immune response and intervene on these risk factors,” said Madison.

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Schools shut, curbs imposed after two die of Nipah virus in Kerela

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Some schools shut and curbs imposed on public gathering in Kerala after two people died of Nipah, a virus from bats or pigs that causes deadly fever.

Also Read: Youth killed another injured in Srinagar road accident

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The virus has no vaccine and a fatality rate ranging from 40 to 75 percent, according to the World Health Organization.

Symptoms include intense fever, vomiting and a respiratory infection, but severe cases can involve seizures and encephalitis, an inflammation of the brain, and result in a coma.

The Nipah virus strain seen in the state was the Bangladesh variant that spreads from human to human and has a high mortality rate, though it is less infectious, the government said. “People living in forest areas have to take the highest precautions,” George had said, adding that the latest case of the Nipah virus originated within five kilometres of a jungle area.

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In the wake of the rising Nipah virus cases, neighbouring Tamil Nadu state announced that travellers coming from Kerala would be subjected to medical tests and those with flu symptoms would be isolated.

700 people including 153 health workers who came in contact with those infected are under observation, health officials said.

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Doctors remove 13 hairpins, 5 safety pins, 5 razor blades from man’s stomach

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A group of talented medical professionals from a private hospital in Puducherry saved a 20-year-old man’s life by successfully removing 13 hairpins, 5 safety pins, and 5 razor blades from his stomach via an endoscopic technique.

The young man was hospitalised with disturbing symptoms, including intense abdominal pain, blood vomiting, and strange bowel motions, according to the experts at the Gastroenterology and Medical Centre (GEM) Hospital. After further inspection, it was discovered that he had 13 hairpins, 5 safety pins, and 5 razor blades in his stomach.

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“He has been dealing with psychiatric issues since childhood. Initially, he denied swallowing any foreign objects. However, during the endoscopic procedure, we discovered a hardened mass in his stomach. This collection of objects is referred to as a ‘foreign body bezoar,’ which could potentially lead to intestinal blockages and perforations,” explained Dr. K Sasikumar, a surgical gastroenterologist who led the medical team, as pee local media reports.

Facing this intricate situation, the team decided to opt for an endoscopic procedure instead of open surgery. Dr. K Sugumaran, another member of the team, stated, “The patient’s parents were also inclined towards avoiding open surgery. We proposed inserting a tube through the mouth to reach the stomach and safely remove these sharp objects. It was a challenging procedure given the nature of the objects.”

The patient was admitted to the hospital on August 7, and the procedure, lasting approximately two hours, took place on August 8. Fortunately, the patient responded positively to the treatment, and he was discharged the following day, on August 9. He even resumed a regular oral diet on the very same evening, as confirmed by Dr. K Sasikumar.

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The dedicated medical team responsible for this extraordinary accomplishment included medical gastroenterologist Dr. G Rajesh and anesthesiologist Dr. Ranjith. Dr. C Palanivelu, Chairman of GEM Hospitals, praised the team for their outstanding efforts in saving the young man’s life.

Doctors suspect that the patient consumed these sharp objects after mixing them with food. The condition of the patient is stable and he has been discharged from hospital.

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Jaundice outbreak in Budgam’s Khansahib: Locals blame poor water quality as one dies, 38 test positive

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The locals have blamed poor water quality for the jaundice outbreak in the Riyar area of Khansahib block in central Kashmir’s Budgam district.

Also Read: Pizza date turns tragic as man falls to death from a terrace while hiding from GF’s father

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The locals told that the Jal Shakti Department has failed to provide safe drinking water in the village, which has led to the outbreak of jaundice and claimed the life of a minor.

“The water is polluted and infected as the water tank hasn’t been cleaned for decades,” they alleged.

The people have requested the authorities to take serious note of the “life-threatening” issue.

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A health official told that so far, 38 jaundice cases have been reported in the area and among them one person has died while the condition of others is stable.

He said that a 10-year-old boy identified as Abid, son of Abdul Salam from Riyar village of Khansahib, who was tested positive for jaundice following a jaundice outbreak, triggered by the supply of contaminated water.

Dr Mir Mushtaq, spokesperson of the Directorate of Health Services Kashmir (DHSK) told that “untiring” efforts are being made at Raiyar to curb jaundice through surveillance and rapid response teams of block Khansahib.

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Simultaneously, the paediatric patients have been seen by the Pediatrician at SDH, Khansahib and blood tests have been conducted for detecting the disease, he said, adding that the screening process is on and thousands of people have been screened so far in the area.

“The situation is under control,” the DHSK spokesperson said.

Already, around 2,000 people have been screened among which 38 have been reported positive, he said, adding that no positive case was reported in the last three days.

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“The ASHA workers of the concerned areas along with health workers have been distributing chlorine tablets and ORS packets among the inhabitants at door steps while field staff are continuously educating the people to take safe drinking water and also demonstrating the steps of hand washing to the people of this area,” Mushtaq said. KNO

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